In Vitro Activity of Caffeic Acid Phenethyl Ester against Different Oral Microorganisms

This was an in vitro study that aimed to evaluate the antimicrobial effect of propolis extract caffeic acid phenethyl ester (CAPE) on four different oral microorganisms. Seven concentrations CAPE (0.2, 0.5, 1, 1.5, 2, 3, and 4 mg/mL) for use against Staphylococcus aureus, Streptococcus mutans, oralis, salivarius were determined using minimum inhibition concentration (MIC), bactericidal (MBC), broth microdilution, well diffusion tests over 6, 12, 24 h, while NaF at 0.05 percent used as a positive control. aureus most affected by CAPE’s inhibitory bacterial growth, whereas S. mutans least affected. oralis had similar MIC MBC values 1 mg/mL 1.5 mg/mL, respectively. The resistant bacteria with 3 followed salivarius, highest viable count following exposure values, lowest. current results growth are promising, both related cariogenic organisms significant. can be employed adjunct dental hygiene substance maintaining good hygiene, has potential therapeutic field health care.